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Valproic acid-d<sub>7</sub>

" in MedChemExpress (MCE) Product Catalog:

2819

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9

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22

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1

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12

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Products

10

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2734

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3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10585AS1
    Valproic acid-d14 sodium

    Sodium Valproate-d<sub>14sub> sodium

    		 Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
    <em>Valproic</em> acid-d14 sodium
  • HY-10585S2
    Valproic acid-d15

    VPA-d<sub>15sub>; 2-Propylpentanoic acid-d<sub>15sub>

    		 HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    <em>Valproic</em> acid-d15
  • HY-10585S
    Valproic acid-d4

    VPA-d<sub>4sub>; 2-Propylpentanoic acid-d<sub>4sub>

    		 HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    <em>Valproic</em> acid-d4
  • HY-10585AS
    Valproic acid-d7 sodium

    Sodium Valproate-d<sub>7sub>(sodium)

    		 Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d7 (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    <em>Valproic</em> acid-d<em>7</em> sodium
  • HY-10585S3
    Valproic acid-d4 sodium

    VPA-d<sub>4sub> sodium; 2-Propylpentanoic acid-d<sub>4sub> sodium

    		 Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d4 (sodium) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
    <em>Valproic</em> acid-d4 sodium
  • HY-10585S1
    Valproic acid-d6

    VPA-d<sub>6sub>; 2-Propylpentanoic acid-d<sub>6sub>

    		 HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d6 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    <em>Valproic</em> acid-d6
  • HY-10585S4
    Valproic acid-d4-1

    VPA-d<sub>4sub>-1; 2-Propylpentanoic acid-d<sub>4sub>-1

    		 Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    <em>Valproic</em> acid-d4-1
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-41463S
    4-(Butylamino)benzoic acid-d7

    4-(Butylamino)benzoic acid-d<sub>7sub>; NSC 44300-d<sub>7sub>; p-Butylaminobenzoic acid-d<sub>7sub>

    		 Isotope-Labeled Compounds Others
    4-(Butylamino)benzoic acid-d7 is the deuterium labeled 4-(Butylamino)benzoic acid[1].
    4-(Butylamino)benzoic acid-d<em>7</em>
  • HY-N2334AS
    Glycochenodeoxycholic acid-d7 sodium

    Chenodeoxycholylglycine-d<sub>7sub> (sodium); Sodium glycochenodeoxycholate-d<sub>7sub>

    		 Endogenous Metabolite Apoptosis Cancer
    Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
    Glycochenodeoxycholic acid-d<em>7</em> sodium
  • HY-10585A
    Valproic acid sodium
    Maximum Cited Publications
    33 Publications Verification

    Sodium Valproate sodium

    		 Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite Infection Neurological Disease Metabolic Disease Cancer
    Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [7].
    <em>Valproic</em> acid sodium
  • HY-10585
    Valproic acid
    Maximum Cited Publications
    33 Publications Verification

    Dipropylacetic acid

    		 Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite Infection Neurological Disease Metabolic Disease Cancer
    Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [7].
    <em>Valproic</em> acid
  • HY-18569S3
    3-Indoleacetic acid-d7

    Indole-3-acetic acid-d<sub>7sub>; 3-IAA-d<sub>7sub>

    		 Endogenous Metabolite Molecular Glues Others
    3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
    3-Indoleacetic acid-d<em>7</em>
  • HY-41494S
    O-Toluic acid-d7

    2-Methylbenzoic acid-d<sub>7sub>

    		 Endogenous Metabolite Others
    O-Toluic acid-d7 is the deuterium labeled o-Toluic acid[1]. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
    O-Toluic acid-d<em>7</em>
  • HY-76547S1
    p-Toluic acid-d7

    4-Methylbenzoic acid-d<sub>7sub>

    		 Endogenous Metabolite Others
    p-Toluic acid-d7 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
    p-Toluic acid-d<em>7</em>
  • HY-107327S
    Carazolol-d7

    (±)-Carazolol-d<sub>7sub>; DL-Carazolol-d<sub>7sub>; Suacron-d<sub>7sub>

    		 Adrenergic Receptor Others
    Carazolol-d7 is the deuterium labeled Carazolol[1].
    Carazolol-d<em>7</em>
  • HY-N0006S
    Demethoxycurcumin-d7

    Curcumin II-d<sub>7sub>; Desmethoxycurcumin-d<sub>7sub>; Monodemethoxycurcumin-d<sub>7sub>

    		 Isotope-Labeled Compounds Apoptosis Autophagy Bacterial Inflammation/Immunology Cancer
    Demethoxycurcumin-d7 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
    Demethoxycurcumin-d<em>7</em>
  • HY-N0610S1
    trans-Cinnamic acid-d7

    trans-3-Phenylacrylic acid-d<sub>7sub>

    		 Bacterial Endogenous Metabolite
    trans-Cinnamic acid-d7 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
    trans-Cinnamic acid-d<em>7</em>
  • HY-66005S2
    Acetaminophen-d7

    Paracetamol-d<sub>7sub>; 4-Acetamidophenol-d<sub>7sub>; 4'-Hydroxyacetanilide-d<sub>7sub>

    		 COX Endogenous Metabolite Histone Acetyltransferase Inflammation/Immunology
    Acetaminophen-d7 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
    Acetaminophen-d<em>7</em>
  • HY-B0389S6
    D-Glucose-d7

    Glucose-d<sub>7sub>; D-(+)-Glucose-d<sub>7sub>; Dextrose-d<sub>7sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    D-Glucose-d77 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
    D-Glucose-d<em>7</em>
  • HY-107352S
    Fosfenopril-d7

    Fosinoprilat-d<sub>7sub>; Fosinoprilic acid-d<sub>7sub>; SQ 27519-d<sub>7sub>

    		 Angiotensin-converting Enzyme (ACE) Interleukin Related NF-κB TNF Receptor Toll-like Receptor (TLR) Isotope-Labeled Compounds Others
    Fosfenopril-d7 is deuterium labeled Fosfenopril.
    Fosfenopril-d<em>7</em>
  • HY-D0711S2
    Indocyanine green-d7

    Foxgreen-d<sub>7sub>; IC Green-d<sub>7sub>; Cardiogreen-d<sub>7sub>

    		 Isotope-Labeled Compounds Fluorescent Dye Others
    Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .
    Indocyanine green-d<em>7</em>
  • HY-12057S1
    Vemurafenib-d7

    PLX4032-d<sub>7sub>; RG7204-d<sub>7sub>; RO5185426-d<sub>7sub>

    		 Isotope-Labeled Compounds Raf Autophagy Cancer
    Vemurafenib-d7 is deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively[1][4]. Vemurafenib induces cell autophagy[5].
    Vemurafenib-d<em>7</em>
  • HY-Y0376S
    DMPA-d7

    Bis-MPA-d<sub>7sub>; Dimethylolpropionic acid-d<sub>7sub>; Nikkamer PA-d<sub>7sub>

    		 Isotope-Labeled Compounds Others
    DMPA-d7 is the deuterium labeled DMPA[1].
    DMPA-d<em>7</em>
  • HY-41700S3
    D-Alanine-d7

    (R)-Alanine-d<sub>7sub>; Ba 2776-d<sub>7sub>; D-α-Alanine-d<sub>7sub>

    		 Endogenous Metabolite
    D-Alanine-d7 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
    D-Alanine-d<em>7</em>
  • HY-135328S
    Norverapamil-d7

    (±)-Norverapamil-d<sub>7sub>; D591-d<sub>7sub>

    		 Calcium Channel P-glycoprotein Drug Metabolite Cardiovascular Disease
    Norverapamil-d7 is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].
    Norverapamil-d<em>7</em>
  • HY-17025S
    Rifabutin-d7

    Ansamycin-d<sub>7sub>; LM-427-d<sub>7sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Rifabutin-d7 is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.
    Rifabutin-d<em>7</em>
  • HY-107855S
    DL-Mevalonolactone-d7

    (±)-Mevalonolactone-d<sub>7sub>; Mevalolactone-d<sub>7sub>

    		 Endogenous Metabolite Metabolic Disease
    DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
    DL-Mevalonolactone-d<em>7</em>
  • HY-B0679S
    Lubiprostone-d7

    RU-0211-d<sub>7sub>; SPI-0211-d<sub>7sub>

    		 Chloride Channel Metabolic Disease
    Lubiprostone-d7 (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation[1][2].
    Lubiprostone-d<em>7</em>
  • HY-50898S1
    Lapatinib-d7 dihydrochloride

    GW572016-dd<sub>7sub> dihydrochloride; GW2016-dd<sub>7sub> dihydrochloride

    		 Isotope-Labeled Compounds EGFR Autophagy Ferroptosis Cancer
    Lapatinib-d7 (dihydrochloride) is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
    Lapatinib-d<em>7</em> dihydrochloride
  • HY-12296S
    Navtemadlin-d7

    AMG 232-d<sub>7sub>; KRT-232-d<sub>7sub>

    		 Isotope-Labeled Compounds MDM-2/p53 E1/E2/E3 Enzyme Cancer
    Navtemadlin-d7 is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
    Navtemadlin-d<em>7</em>
  • HY-13720AS
    Pergolide-d7 mesylate

    Pergolide methanesulfonate-d<sub>7sub>; LY127809-d<sub>7sub>

    		 Isotope-Labeled Compounds Dopamine Receptor Neurological Disease
    Pergolide-d7 (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].
    Pergolide-d<em>7</em> mesylate
  • HY-12785S1
    Albendazole sulfoxide-d7

    Ricobendazole-d<sub>7sub>; Albendazole oxide-d<sub>7sub>

    		 Isotope-Labeled Compounds Parasite Infection
    Albendazole sulfoxide-d7 is the deuterium labeled Albendazole sulfoxide. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1].
    Albendazole sulfoxide-d<em>7</em>
  • HY-14268S1
    Febuxostat-d7

    TEI 6720-d<sub>7sub>; TMX 67-d<sub>7sub>

    		 Isotope-Labeled Compounds Xanthine Oxidase Metabolic Disease Cancer
    Febuxostat-d7 is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].
    Febuxostat-d<em>7</em>
  • HY-B1674S4
    (±)-Leucine-d7

    DL-Leucine-d<sub>7sub>; (RS)-Leucine-d<sub>7sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial
    (±)-Leucine-d7 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].
    (±)-Leucine-d<em>7</em>
  • HY-N0650S11
    L-Serine-d7

    (-)-Serine-d<sub>7sub>; (S)-Serine-d<sub>7sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite
    L-Serine-d7 is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
    L-Serine-d<em>7</em>
  • HY-N7745S
    Glucosylsphingosine-d7

    Glucopsychosine-d<sub>7sub>; Lyso-Gb1-d<sub>7sub>

    		 Isotope-Labeled Compounds Others
    Glucosylsphingosine-d7 is deuterium labeled Glucosylsphingosine.
    Glucosylsphingosine-d<em>7</em>
  • HY-135853S
    Molnupiravir-d7

    EIDD-2801-d<sub>7sub>; MK-4482-d<sub>7sub>

    		 SARS-CoV Influenza Virus Inflammation/Immunology
    Molnupiravir-d7 is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza[1][2].
    Molnupiravir-d<em>7</em>
  • HY-14275S1
    Verapamil-d7

    (±)-Verapamil-d<sub>7sub>; CP-16533-1-d<sub>7sub>

    		 Isotope-Labeled Compounds Calcium Channel P-glycoprotein Cytochrome P450 Metabolic Disease Cancer
    Verapamil-d7 is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .
    Verapamil-d<em>7</em>
  • HY-101047S
    D-erythro-Sphingosine-d7

    Erythrosphingosine-d<sub>7sub>; erythro-C18-Sphingosine-d<sub>7sub>; trans-4-Sphingenine-d<sub>7sub>

    		 PKC Phosphatase Endogenous Metabolite Cancer
    D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].
    D-erythro-Sphingosine-d<em>7</em>
  • HY-B0763S2
    Ibudilast-d7-1

    KC-404-d<sub>7sub>-1; AV-411-d<sub>7sub>-1; MN-166-d<sub>7sub>-1

    		 Phosphodiesterase (PDE)
    Ibudilast-d7-1 is the deuterium labeled Ibudilast[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[2].
    Ibudilast-d<em>7</em>-1
  • HY-Y1772S
    1-Iodo-4-methylbenzene-d7

    p-Iodotoluene-d<sub>7sub>; p-Methyliodobenzene-d<sub>7sub>; p-Tolyl iodide-d<sub>7sub>

    		 Isotope-Labeled Compounds Others
    1-Iodo-4-methylbenzene-d7 is the deuterium labeled 1-Iodo-4-methylbenzene[1].
    1-Iodo-4-methylbenzene-d<em>7</em>
  • HY-124087
    (±)-2-Propyl-4-pentenoic acid

    4-en-VPA; 2-Allylpentanoic acid

    		 Drug Metabolite Others
    (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity .
    (±)-2-Propyl-4-pentenoic acid
  • HY-14291S1
    Vildagliptin-d7

    LAF237-d<sub>7sub>; NVP-LAF 237-d<sub>7sub>

    		 Isotope-Labeled Compounds Dipeptidyl Peptidase Ferroptosis Apoptosis Metabolic Disease
    Vildagliptin-d7 is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1].
    Vildagliptin-d<em>7</em>
  • HY-B1178S2
    (Rac)-Cotinine-d7

    (±)-Cotinine-d<sub>7sub>; (Rac)-NIH-10498-d<sub>7sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    (Rac)-Cotinine-d7 is deuterium labeled Cotinine.
    (Rac)-Cotinine-d<em>7</em>
  • HY-N2026S
    Propylparaben-d7

    Propyl parahydroxybenzoate-d<sub>7sub>; Propyl 4-hydroxybenzoate-d<sub>7sub>

    		 Isotope-Labeled Compounds Others
    Propylparaben-d7 (Propyl parahydroxybenzoate-d7)is the deuterium labeledPropylparaben(HY-N2026) . Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats .
    Propylparaben-d<em>7</em>
  • HY-112499S
    Menaquinone-7-d7

    Vitamin K2-7-d<sub>7sub>; Vitamin K2(35)-d<sub>7sub>; Vitamin MK-7-d<sub>7sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
    Menaquinone-<em>7</em>-d<em>7</em>
  • HY-10585B
    Valproic acid (sodium)(2:1)

    VPA (sodium)(2:1); 2-Propylpentanoic acid (sodium)(2:1)

    		 HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite Infection Neurological Disease Metabolic Disease Cancer
    Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium (2:1) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [7].
    <em>Valproic</em> acid (sodium)(2:1)
  • HY-B0978S1
    Diethyltoluamide-d7

    DEET-d<sub>7sub>; N,N-Diethyl-m-toluamide-d<sub>7sub>

    		 Parasite Infection
    Diethyltoluamide-d7 is the deuterium labeled Diethyltoluamide[1]. Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects[2].
    Diethyltoluamide-d<em>7</em>

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